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Co-Authors
- R. Pratap
- R. C. Gupta
- R. Chander
- A. K. Khanna
- Vinita Singh
- N. K. Kapoor
- D. Raina
- S. Singh
- A. Ghatak
- O. P. Asthana
- S. Nityanand
- Sukh Dev
- Nitya Anand
- Sachin D. Ghude
- G. S. Bhat
- Thara Prabhakaran
- R. K. Jenamani
- D. M. Chate
- P. D. Safai
- A. K. Karipot
- M. Konwar
- Prakash Pithani
- V. Sinha
- P. S. P. Rao
- S. A. Dixit
- S. Tiwari
- K. Todekar
- S. Varpe
- D. S. Bisht
- P. Murugavel
- Kaushar Ali
- Usha Mina
- M. Dharua
- J. Rao
- B. Padmakumari
- A. Hazra
- N. Nigam
- U. Shende
- D. M. Lal
- B. P. Chandra
- A. K. Mishra
- A. Kumar
- H. Hakkim
- H. Pawar
- P. Acharja
- Rachana Kulkarni
- C. Subharthi
- B. Balaji
- M. Varghese
- S. Bera
- M. Rajeevan
- N. Chattopadhyay
- A. K. Sahai
- P. Guhathakurta
- S. Dutta
- S. D. Attri
- R. Balasubramanian
- K. Malathi
- Swati Chandras
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Srivastava, A. K.
- 3β-Hydroxy-5,16-Pregnadien-20-One Exhibits both Hypolipidemic and Hypoglycemic Activities
Abstract Views :326 |
PDF Views:110
Authors
R. Pratap
1,
R. C. Gupta
1,
R. Chander
1,
A. K. Khanna
1,
Vinita Singh
1,
N. K. Kapoor
1,
A. K. Srivastava
1,
D. Raina
1,
S. Singh
1,
A. Ghatak
1,
O. P. Asthana
1,
S. Nityanand
1,
Sukh Dev
2,
Nitya Anand
1
Affiliations
1 Central Drug Research Institute, Lucknow 226 001, IN
2 Ambedkar Research Centre, Delhi University South Campus, New Delhi 110 021, IN
1 Central Drug Research Institute, Lucknow 226 001, IN
2 Ambedkar Research Centre, Delhi University South Campus, New Delhi 110 021, IN
Source
Current Science, Vol 108, No 9 (2015), Pagination: 1634-1646Abstract
The increasing incidence of disorders due to metabolic syndrome, which include hyperlipidemias, diabetes and hypertension, has taken serious dimension world over, including in India, and has become a matter of deep concern. Drugs which can inhibit more than one disorder of this syndrome would add much therapeutic value to its management. 3β -Hydroxy-5,16- pregnadien-20-one (80-574, 2), selected based on the structural lead of the presence of a β -enone pharmacophore in/around ring D of Guggulsterone (1), the main active constituent of the phytopharmaceutical Gugulip developed at CDRI, Lucknow from the Ayurvedic herbal drug Gum Guggul, has been found to exhibit both hypolipidemic and hypoglycemic activities in the conventional experimental animal models used for studying these activities. In mode of hypolipidemic action studies in high fat diet-fed rats, compound 80-574 was found to enhance lipolysis of serum lipoproteins, enhance the uptake of LDL by hepatocyte membranes, indicating increased catabolism of LDL, and caused increased faecal excretion of bile acids indicating enhanced mobilization of cholesterol from fatty deposits. Compound 80-574 also exhibited antioxidant activity in in vitro and in vivo experimental models, and protected LDL against oxidation, indicating protection against atherogenesis. Compound 80-574 also exhibited moderate inhibition of cholesterol biosynthesis in liver slices. Treatment with 80-574 also improves glucose tolerance in diabetic rats. With these multiple sites of hypolipidemic action accompanied with its hypoglycemic activity, compound 80-574 appears a promising candidate for the treatment of dyslipidemias and diabetes and thus for management of metabolic syndrome. A synoptic view of the various functional activities exhibited by compound 80-574 is presented in this article.Keywords
Diabetes, Lipoproteins, Lipid Peroxides, Triglycerides.- Winter Fog Experiment Over the Indo-Gangetic Plains of India
Abstract Views :311 |
PDF Views:87
Authors
Sachin D. Ghude
1,
G. S. Bhat
2,
Thara Prabhakaran
1,
R. K. Jenamani
3,
D. M. Chate
1,
P. D. Safai
1,
A. K. Karipot
4,
M. Konwar
1,
Prakash Pithani
1,
V. Sinha
5,
P. S. P. Rao
1,
S. A. Dixit
1,
S. Tiwari
1,
K. Todekar
1,
S. Varpe
1,
A. K. Srivastava
1,
D. S. Bisht
1,
P. Murugavel
1,
Kaushar Ali
1,
Usha Mina
6,
M. Dharua
1,
J. Rao
1,
B. Padmakumari
1,
A. Hazra
1,
N. Nigam
3,
U. Shende
3,
D. M. Lal
1,
B. P. Chandra
5,
A. K. Mishra
5,
A. Kumar
5,
H. Hakkim
5,
H. Pawar
5,
P. Acharja
1,
Rachana Kulkarni
1,
C. Subharthi
1,
B. Balaji
1,
M. Varghese
1,
S. Bera
1,
M. Rajeevan
7
Affiliations
1 Indian Institute of Tropical Meteorology, Pashan, Pune 411 008, IN
2 Indian Institute of Science, Bengaluru 560 012, IN
3 India Meteorological Department, New Delhi 110 003, IN
4 Savitribai Phule Pune University, Pune 411 007, IN
5 Indian Institute of Science Education and Research Mohali, Mohali 140 306, IN
6 Indian Agricultural Research Institute, Pusa, New Delhi 110 012, IN
7 Ministry of Earth Sciences, Government of India, New Delhi 110 003, IN
1 Indian Institute of Tropical Meteorology, Pashan, Pune 411 008, IN
2 Indian Institute of Science, Bengaluru 560 012, IN
3 India Meteorological Department, New Delhi 110 003, IN
4 Savitribai Phule Pune University, Pune 411 007, IN
5 Indian Institute of Science Education and Research Mohali, Mohali 140 306, IN
6 Indian Agricultural Research Institute, Pusa, New Delhi 110 012, IN
7 Ministry of Earth Sciences, Government of India, New Delhi 110 003, IN
Source
Current Science, Vol 112, No 04 (2017), Pagination: 767-784Abstract
The objectives of the Winter Fog Experiment (WIFEX) over the Indo-Gangetic Plains of India are to develop better now-casting and forecasting of winter fog on various time- and spatial scales. Maximum fog occurrence over northwest India is about 48 days (visibility <1000 m) per year, and it occurs mostly during the December-February time-period. The physical and chemical characteristics of fog, meteorological factors responsible for its genesis, sustenance, intensity and dissipation are poorly understood. Improved understanding on the above aspects is required to develop reliable forecasting models and observational techniques for accurate prediction of the fog events. Extensive sets of comprehensive ground-based instrumentation were deployed at the Indira Gandhi International Airport, New Delhi. Major in situ sensors were deployed to measure surface micro-meteorological conditions, radiation balance, turbulence, thermodynamical structure of the surface layer, fog droplet and aerosol microphysics, aerosol optical properties, and aerosol and fog water chemistry to describe the complete environmental conditions under which fog develops. In addition, Weather Forecasting Model coupled with chemistry is planned for fog prediction at a spatial resolution of 2 km. The present study provides an introductory overview of the winter fog field campaign with its unique instrumentation.Keywords
Aerosols, Atmospheric Profiles, Forecasting, Winter Fog.- Impact of Observed Climate Change on the Classification of Agroclimatic Zones in India
Abstract Views :211 |
PDF Views:73
Authors
N. Chattopadhyay
1,
A. K. Sahai
1,
P. Guhathakurta
1,
S. Dutta
1,
A. K. Srivastava
1,
S. D. Attri
2,
R. Balasubramanian
1,
K. Malathi
1,
Swati Chandras
1
Affiliations
1 India Meteorological Department, Shivajinagar, Pune 411 005, IN
2 India Meteorological Department, New Delhi 110 003, IN
1 India Meteorological Department, Shivajinagar, Pune 411 005, IN
2 India Meteorological Department, New Delhi 110 003, IN
Source
Current Science, Vol 117, No 3 (2019), Pagination: 480-486Abstract
The classification of agroclimatic zones in India was made in the 1990s for identifying priorities and developing strategies for location-specific and need-based research as well as overall agricultural development in the country. Long-term climatic parameters, particularly temperature and rainfall along with soil and crop information were used for the classification of agroclimatic zones. It has been documented with a fair degree of accuracy that overall climate is changing, particularly with respect to temperature over the Indian region. Thus it is anticipated that in the recent past, climate change may be reflected in the agroclimatic zones as well and ultimately affect the criteria of their classification based on climatic parameters. The objective of the present study is to examine the trends and spatial/temporal variability of temperature, rainfall, rainy days, and heavy rainfall in different agroclimatic zones of the country, which may help in better understanding of the further initiatives on reclassification of agroclimatic zones, if required. Using various long-term gridded data from 1985 and instrumental datasets starting from 1951 to 1980, studies have been made to observe changes in different components of the climatic variables, i.e. temperature and rainfall. It has been observed that there are significant changes in temperature and rainfall, both temporally and spatially, across India and there is a definite shift in temperature and rainfall patterns in the recent past compared to 1951–1980. It has also been inferred that there is a need to reconsider the classification of agroclimatic zones in India under the scenario of observed climate changes in the country.Keywords
Agroclimatic Zones, Classification, Climatic Parameters, Climate Change.References
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- Srivastava, A. K., Kothawale, D. R. and Rajeevan, M. N., Variability and long-term changes in surface air temperatures over the Indian subcontinent. In Observed Climate Variability and Change over the Indian Region, Springer, Singapore, 22 November 2016, 2017, 1st edn, pp. 17–36.
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- Rupa Kumar, K., Pant, G. B., Parthasarathy, B. and Sontakke, N. A., Spatial and sub-seasonal patterns of the long-term trends of Indian summer monsoon rainfall. Int. J. Climatol., 1992, 12, 257–268.
- Guhathakurta, P. and Rajeevan, M., Trends in rainfall pattern over India. Int. J. Climatol., 2008, 28, 1453–1469.
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